Sales of Pepsin to Increase at 4.7% CAGR as Applications across Pharmaceutical Industry Surges

Pepsin market value is anticipated to increase at a CAGR 4.7% over the forecast period of 2021 to 2031, and is set to surpass a valuation of US$ 4.8 Bn by 2031, as per Fact.MR’s detailed industry analysis. In 2020, the market enjoyed a valuation of US$ 2.9 Bn, which is equivalent to 30% of the global enzymes market.

Pepsin Market Size (2021) USD 3 Bn
Market Forecasted Value (2031) USD 4.8 Bn
Global Growth Rate CAGR 4.7%
Europe Market Share One-third


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Pepsin is a naturally occurring digestive protein found in the highly acidic environment of the stomach. For commercial applications, pepsin is used extensively as a digestive enzyme supplement in the pharmaceutical industry.

Of the end-use industries considered, consumption of pepsin can be significantly observed in pharmaceuticals, which accounts for nearly 50% of overall pepsin demand, owing to extensive utilization in the manufacture of lifesaving drugs.

Demand Analysis of Pepsin from 2016 to 2020 Vs Market Outlook for 2021 to 2031

Over the 2016-2020 historical period, the pepsin market expanded at 2.9% CAGR, on the back of high pepsin adoption as an intermediate in digestive drugs and as a protein supplement, as per Fact.MR – a market research and competitive intelligence provider. In digestive drugs, pepsin is used as a degrading or proteolytic enzyme that directly impacts the digestive system.

Rising application of pepsin, which is an endopeptidase, in the pharmaceutical industry, was one of the prominent factors for the growth of pepsin sales during 2016-2020. In terms of value, pepsin revenue generated by the pharmaceutical industry reached US$ 1.45 Bn in 2020. Considering the forecast period of 2021-2031, the pharmaceutical industry is anticipated to witness substantial growth, which provides a positive outlook for pepsin manufacturers.

Additionally, application of pepsin in the industrial sector is increasing so as to remove unwanted remaining tissue from partially processed hide in leather. Furthermore, pepsin is applied during silver recovery from discarded photographic films by digesting the gelatin layer that holds the silver.

All these application have been identified as niche applications of pepsin that are expected to witness steady growth over the coming years.

Below points summarize the market over the long-run forecast period:

  • Pharmaceutical industry is a prominent consumer of pepsin accounting for over 50% market share in 2020.
  • Application of pepsin in the industrial sector is anticipated to increase at a steady pace over the decade.
  • China is the centre of attraction for pepsin manufacturers as the country has a robust pharmaceutical sector.
  • Application of pepsin in food & feed is anticipated to increase at a CAGR 2.5% during 2016-2020.

What are the Prospects for Pepsin as a Food Additive?

Demand for pepsin as a food additive has significantly risen in the past half- decade. For instance, pepsin is commercially used in the processing of soy protein and gelatin. Moreover, pepsin is also used in applications ranging from poultry, meat, and cream novelties such as ice cream, nutritional beverages, and dairy products.

In addition, pepsin is used as a substitute for rennin in the production of cheese. Rise in demand for cheese and ease of production of the same with pre-integrated processes, including pepsin, will bolster pepsin demand over the long-run forecast period.

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